Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;34(3):e23084.
doi: 10.1002/jcla.23084. Epub 2019 Nov 11.

Evaluation of lipoprotein-associated phospholipase A2, serum amyloid A, and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction

Liang Tao  1 , Wang ShiChuan  1 , Zhang DeTai  1 , Hu Lihua  1
Affiliations

Evaluation of lipoprotein-associated phospholipase A2, serum amyloid A, and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction

Liang Tao et al. J Clin Lab Anal. 2020 Mar.

Abstract

Objective: The aim of this study was to explore the clinical values of combined detection of lipoprotein-associated phospholipase A2 (Lp-PLA2), serum amyloid A (SAA), and plasma fibrinogen (FIB) in the diagnosis of acute cerebral infarction (ACI).

Methods: A case-control study including 100 hospitalized patients with ACI and 47 healthy controls was carried out. The level of Lp-PLA2, SAA, and FIB was detected, respectively, and their clinical values were analyzed. Carotid lesions and neurological impairment were also analyzed in each patient.

Results: The level of Lp-PLA2, SAA, and FIB in the ACI group was significantly higher than that of the controls, and the three biomarkers showed a significant positive correlation and were considered as risk factors for ACI. The area under the curve (AUC) for Lp-PLA2, SAA, and FIB was 0.858, 0.743, and 0.672, respectively. When three biomarkers were used in combination, the AUC was 0.879. Compared with the other groups, the levels of three biomarkers in bilateral carotid plaque ACI group were all significantly higher. In addition, the level of Lp-PLA2 and SAA in ACI patients with severe neurological impairment was also significantly higher than that of the mild-to-moderate group.

Conclusion: Lp-PLA2 combined with SAA and FIB had a high clinical value for rapid diagnosis and prediction of ACI. These biomarkers were also significantly associated with the formation of bilateral carotid atherosclerotic plaques and the severe neurological impairment in ACI patients.

Keywords: acute cerebral infarction; atherosclerosis; fibrinogen; lipoprotein-associated phospholipase A2; serum amyloid A.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The ROC curve of Lp‐PLA2, SAA, and FIB for discrimination between patients in ACI and non‐ACI group
See this image and copyright information in PMC

References

    1. Roth GA, Johnson CO, Nguyen G, et al. Methods for estimating the global burden of cerebrovascular diseases. Neuroepidemiology. 2015;45(3):146‐151. - PubMed
    1. Kara H, Akinci M, Degirmenci S, et al. High‐sensitivity C‐reactive protein, lipoprotein‐related phospholipase A2, and acute ischemic stroke. Neuropsychiatr Dis Treat. 2014;10:1451‐1457. - PMC - PubMed
    1. Chen L, Yang Q, Ding R, Liu D, Chen Z. Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‐2 and MMP‐9 were associated with acute cerebral infarction. Exp Ther Med. 2018;16(6):5253‐5257. - PMC - PubMed
    1. Liu H, Yao Y, Wang Y, et al. Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: a cross‐sectional study. J Cell Mol Med. 2018;22(10):5145‐5150. - PMC - PubMed
    1. Fu X, Liu Q, Zeng X, Huang S, Huang R, Gao Q. Association between cerebral arterial stiffness and large artery atherosclerosis in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2018;27(11):2993‐3000. - PubMed