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Case Reports
. 2020 Feb;22(1):e13210.
doi: 10.1111/tid.13210. Epub 2019 Nov 25.

Jamestown Canyon virus encephalitis in a heart transplant patient

Wajih Askar  1 , Puneet Menaria  2 , Vinay Thohan  3 , Charles F Brummitt  4
Affiliations
Case Reports

Jamestown Canyon virus encephalitis in a heart transplant patient

Wajih Askar et al. Transpl Infect Dis. 2020 Feb.

Abstract

Jamestown Canyon virus (JtCV) is an arbovirus and a member of the California serogroup. To our knowledge, all the cases of JtCV have been reported in immunocompetent patients since it was first detected in 1997. We report a case of JtCV encephalitis in a solid organ transplant patient. A 48-year-old woman from Wisconsin had multiple hospital admissions for symptoms of progressive confusion, visual hallucinations, and inability to perform self-care. Initial evaluation was significant for lymphocytes in cerebrospinal fluid (CSF), and multiple infectious and metabolic causes were excluded. Further investigation found JtCV IgM in serum, and CSF. The patient's clinical course was compatible with JtCV encephalitis, and she was treated with ribavirin in addition to reduction of her immunosuppressive medications. She showed gradual and significant improvement in her mental and functional status. JtCV can cause a variety of symptoms that range from a flu-like syndrome to encephalitis. There have been an increased number of reported cases in recent years which is attributed to increased physician awareness and the availability of laboratory testing. Optimal treatment is still not known.

Keywords: Jamestown Canyon virus; PRNT; arbovirus; heart transplant; solid organ transplant; viral encephalitis.

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References

REFERENCES

    1. Huang C, Campbell W, Grady L, Kirouac I, LaForce FM. Diagnosis of Jamestown Canyon encephalitis by polymerase chain reaction. Clin Infect Dis. 1999;28:1294-1297.
    1. Pastula DM, Hoang Johnson DK, White JL, Dupuis AP 2nd, Fischer M, Staples JE. Jamestown Canyon virus disease in the United States-2000-2013. Am J Trop Med Hyg. 2015;93:384-389.
    1. Savard M, Paradis A, Francoeur CL. Jamestown Canyon encephalitis with NORSE and electrographic response to ribavirin: a case report. Epilepsia Open. 2018;3(2):286-289.
    1. Haidar G, Singh N. Viral infections in solid organ transplant recipients: novel updates and a review of the classics. Curr Opin Infect Dis. 2017;30(6):579-588.
    1. Lyons JL, Schaefer PW, Cho TA, Azar MM. Case 34-2017. A 76-year-old man with fever, weight loss, and weakness. N Engl J Med. 2017;377:1878-1886.

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