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Case Reports
. 2021 Mar 1;43(2):e215-e218.
doi: 10.1097/MPH.0000000000001654.

Response to Denosumab in 2 Children With Recurrent Giant Cell Tumor of the Bone With Pulmonary Metastasis

Kiranmye Reddy  1   2 , Lorimar Ramirez  1   2 , Kamlesh Kukreja  1   3 , Rajkumar Venkatramani  1   2
Affiliations
Case Reports

Response to Denosumab in 2 Children With Recurrent Giant Cell Tumor of the Bone With Pulmonary Metastasis

Kiranmye Reddy et al. J Pediatr Hematol Oncol. .

Abstract

Giant cell tumor of the bone (GCTB) is an uncommon bone tumor, usually localized, and rarely presents at <20 years of age. Denosumab, a fully human monoclonal antibody against RANKL (receptor activator of nuclear factor κB ligand), is approved for the treatment of unresectable GCTB in skeletally mature individuals. We present a case series of 2 pediatric patients with recurrent GCTB with pulmonary metastasis, with clinical response to denosumab therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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