Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Oct 1;168(4):1475-80.
doi: 10.1084/jem.168.4.1475.

Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus

S Minota  1 , B Cameron, W J Welch, J B Winfield
Affiliations

Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus

S Minota et al. J Exp Med. .

Abstract

Serum from patients with systemic lupus erythematosus (SLE) frequently contain IgM and IgG autoantibodies to the constitutively expressed 73-kD/pI 5.5 member of the hsp70 family of heat shock proteins, as determined by one-dimensional (SDS-PAGE) and two-dimensional (IEF/SDS-PAGE) immunoblotting, and by solid-phase SLE Ig immunoprecipitation experiments using hsp70 protein-specific mAbs as probes. Autoantibodies to hsp70 also were detected in a minority of sera from patients with other rheumatic or viral diseases, but not in normal sera. These data may provide additional insight into etiologic and pathophysiologic mechanisms in this and related autoimmune disorders.

PubMed Disclaimer

References

    1. J Biol Chem. 1975 May 25;250(10):4007-21 - PubMed
    1. Adv Immunol. 1982;33:167-240 - PubMed
    1. Arthritis Rheum. 1982 Nov;25(11):1271-7 - PubMed
    1. Cell. 1983 Nov;35(1):101-7 - PubMed
    1. J Cell Biol. 1986 Aug;103(2):321-5 - PubMed

Publication types