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Comment
. 2019 Nov 11;36(5):461-463.
doi: 10.1016/j.ccell.2019.10.012.

Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy

Jessica L Hopkins  1 , Lee Zou  2
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Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy

Jessica L Hopkins et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Quereda and colleagues report that a newly developed specific inhibitor of CDK12/13, SR-4835, sensitizes triple-negative breast cancer cells to PARP inhibitors and DNA-damaging chemotherapeutics by reducing expression of the genes in the DNA damage response pathway.

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