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Comment
. 2019 Nov 11;36(5):466-467.
doi: 10.1016/j.ccell.2019.10.009.

Tumor Neoantigens: When Too Much of a Good Thing Is Bad

Anne Trinh  1 , Kornelia Polyak  2
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Tumor Neoantigens: When Too Much of a Good Thing Is Bad

Anne Trinh et al. Cancer Cell. .
Free article

Abstract

Immunotherapy has been the most effective in tumors with high mutational burden. However, a recent study in Cell by Wolf et al. demonstrates that high intratumor heterogeneity (ITH) for cancer neoantigens paradoxically attenuates anti-tumor immune responses, suggesting a need to quantify ITH to improve patient selection for checkpoint blockade therapy.

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  • UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma.
    Wolf Y, Bartok O, Patkar S, Eli GB, Cohen S, Litchfield K, Levy R, Jiménez-Sánchez A, Trabish S, Lee JS, Karathia H, Barnea E, Day CP, Cinnamon E, Stein I, Solomon A, Bitton L, Pérez-Guijarro E, Dubovik T, Shen-Orr SS, Miller ML, Merlino G, Levin Y, Pikarsky E, Eisenbach L, Admon A, Swanton C, Ruppin E, Samuels Y. Wolf Y, et al. Cell. 2019 Sep 19;179(1):219-235.e21. doi: 10.1016/j.cell.2019.08.032. Epub 2019 Sep 12. Cell. 2019. PMID: 31522890 Free PMC article.

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