Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Nov 12;20(22):5645.
doi: 10.3390/ijms20225645.

Cell-Free Nucleic Acids

Affiliations
Editorial

Cell-Free Nucleic Acids

Balint Nagy. Int J Mol Sci. .

Abstract

The discovery of cell-free DNA (cfDNA) dates back to 1948, when Mandel and Metais found it in the sera of cancer patients [...].

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

References

    1. Mandel P., Metais P. Les acides nucléiques du plasma sanguine chez l’homme. CR Seances Soc. Biol. Fil. 1948;142:241–243. - PubMed
    1. Tan E.M., Schur P.H., Carr R.I., Kunkel H.G. Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J. Clin. Investig. 1966;45:1732–1740. doi: 10.1172/JCI105479. - DOI - PMC - PubMed
    1. Leon S.A., Shapiro B., Sklaroff D.M., Yaros M.J. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res. 1977;37:646–650. - PubMed
    1. Lo D.Y.M., Corbetta N., Chamberlain P.F., Rai V., Sargent I.L., Redman C.W., Wainscoat J.S. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997;350:485–487. doi: 10.1016/S0140-6736(97)02174-0. - DOI - PubMed
    1. Palomaki G.E., Kloza E.M., Lambert-Messerlian G.M., Haddow J.E., Neveux L.M., Ehrich M., van den Boom D., Bombard A.T., Deciu C., Grody W.W., et al. DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study. Genet. Med. 2011;13:913–920. doi: 10.1097/GIM.0b013e3182368a0e. - DOI - PubMed

Publication types

LinkOut - more resources