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. 2019 Nov 6:7:50.
doi: 10.1186/s40560-019-0402-4. eCollection 2019.

A comprehensive protocol for ventilator weaning and extubation: a prospective observational study

Kenichi Nitta  1 , Kazufumi Okamoto  1 , Hiroshi Imamura  1 , Katsunori Mochizuki  1 , Hiroshi Takayama  1 , Hiroshi Kamijo  1 , Mayumi Okada  1 , Kanako Takeshige  1 , Yuichiro Kashima  1 , Takahisa Satou  1
Affiliations

A comprehensive protocol for ventilator weaning and extubation: a prospective observational study

Kenichi Nitta et al. J Intensive Care. .

Abstract

Background: Ventilator weaning protocols have been shown to reduce the duration of mechanical ventilation (MV), intensive care unit length of stay, and resource use. However, weaning protocols have not significantly affected mortality or reintubation rates. The extubation process is a critical component of respiratory care in patients who receive MV. Post-extubation respiratory failure (PERF) is a common event associated with significant morbidity and mortality. We hypothesized that a comprehensive protocol for ventilator weaning and extubation would be effective for preventing PERF and reintubation and reducing mortality in critically ill patients.

Methods: A ventilator weaning and extubation protocol was developed. The protocol consisted of checklists across four evaluations: spontaneous breathing trial, extubation, prophylactic non-invasive positive pressure ventilation (NPPV), and evaluation after extubation. Observational data were collected after implementing the protocol in patients admitted to the Advanced Emergency and Critical Care Center of Shinshu University Hospital. Not only outcomes of patients but also influences of each component of the protocol on the clinical decision-making process were investigated. Further, a comparison between PERF and non-PERF patients was performed.

Results: A total of 464 consecutive patients received MV for more than 48 h, and 248 (77 women; mean age, 65 ± 17 years) were deemed eligible. The overall PERF and reintubation rates were 9.7% and 5.2%, respectively. Overall, 54.1% of patients with PERF received reintubation. Hospital stay and mortality were not significantly different between PERF and non-PERF patients (p = 0.16 and 0.057, respectively). As a result, the 28-day and hospital mortality were 1.2% and 6.9%, respectively.

Conclusions: We found that the rates of PERF, reintubation, and hospital mortality were lower than those in previous reports even with nearly the same degree of severity at extubation. The comprehensive protocol for ventilator weaning and extubation may prevent PERF and reintubation and reduce mortality in critically ill patients.

Keywords: Comprehensive protocol for ventilator weaning and extubation; Hospital mortality; Post-extubation respiratory failure; Reintubation.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Protocol flow chart. SBT, spontaneous breathing trial; PERF, post-extubation respiratory failure; NPPV, non-invasive positive pressure ventilation
Fig. 2
Fig. 2
Details of a comprehensive protocol for ventilator weaning and extubation. SBT, spontaneous breathing trial; PSV, pressure support ventilation; PEEP, positive end-expiratory pressure; RR, respiratory rate; RSBI, rapid shallow breathing index; SaO2, oxygen saturation; HR, heart rate; PERF, post-extubation respiratory failure; APACHE II, Acute Physiology and Chronic Health Evaluation II; NPPV, non-invasive positive pressure ventilation; SpO2, arterial oxygen saturation
Fig. 3
Fig. 3
Flow chart of the study patients. MV, mechanical ventilation; PERF, post-extubation respiratory failure; NPPV, non-invasive positive pressure ventilation
See this image and copyright information in PMC

Comment in

  • Strategies for Liberation from Mechanical Ventilation.
    Reaume M, Noor Ul Husnain SM, Kapadia D, Tatem G. Reaume M, et al. Am J Respir Crit Care Med. 2021 May 1;203(9):1183-1185. doi: 10.1164/rccm.202006-2312RR. Am J Respir Crit Care Med. 2021. PMID: 33631088 No abstract available.

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