Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019;72(3):296-301.
doi: 10.5173/ceju.2019.1900. Epub 2019 Sep 2.

Paternal contribution to embryonic competence

Daniel Stein  1   2 , Chierika Ukogu  2 , Amanda Ganza  2 , Dmitry Gounko  1 , Joseph Lee  1 , Natan Bar-Chama  1   3 , Alan B Copperman  1   2
Affiliations

Paternal contribution to embryonic competence

Daniel Stein et al. Cent European J Urol. 2019.

Abstract

Introduction: The effect of paternal characteristics on embryo development and the outcome of preimplantation genetic testing for aneuploidy have not been extensively explored. This study investigates the association of sperm parameters, insemination, and extraction techniques, with the rate of embryo aneuploidy. This study sought to evaluate the association between male factor infertility and embryo aneuploidy.

Material and methods: Patients underwent in vitro fertilization using intracytoplasmic sperm injection, with preimplantation genetic testing for aneuploidy. Patients were divided into four groups by sperm parameters: Group A: oligozoospermia (sperm concentration <10 million, morphology > 4%); Group B: teratozoospermia (sperm concentration >10 million, morphology <4%); Group C: oligozoospermia and teratozoospermia (sperm concentration <10 million, morphology <4%); Group D: controls. Additionally, couples were divided into three categories by days of abstinence: Group A: <2; Group B: 2-7; and Group C: >7.

Results: A total of 4108 in vitro fertilization cycles with preimplantation genetic testing for aneuploidy were analyzed. After controlling for parental age and follicle count, the rate of embryo aneuploidy was not affected by duration of abstinence, sperm parameters, or the source of the sperm sample.

Conclusions: Numerous factors related to sperm source and quality were evaluated, and a minimal influence on the rate of embryo aneuploidy was observed.

Keywords: aneuploidy; male infertility; preimplantation genetic testing; sperm; testicular sperm extraction.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Hamada A, Esteves SC, Nizza M, Agarwal A. Unexplained male infertility: diagnosis and management. Int Braz J Urol. 2012;38:576–594. - PubMed
    1. Ferlin A, Raicu F, Gatta V, Zuccarello D, Palka G, Foresta C. Male infertility: role of genetic background. Reprod Biomed Online. 2007;14:734–745. - PubMed
    1. Tempest HG, Martin RH. Cytogenetic risks in chromosomally normal infertile men. Curr Opin Obstet Gynecol. 2009;21:223–227. - PubMed
    1. Patrizio P. Intracytoplasmic sperm injection (ICSI): potential genetic concerns. Hum Reprod. 1995;10:2520–2523. - PubMed
    1. Munné S, Alikani M, Tomkin G, Grifo J, Cohen J. Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertil Steril. 1995;64:382–391. - PubMed

LinkOut - more resources