The Association between Body Mass Index and Vitamin D Supplement Use among Adults in the United States

Abstract

Background Obesity has been consistently associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations. BMI status also has a major impact on 25(OH)D levels among vitamin D supplement users. In our cross-sectional study, we aimed to discuss the prevalence of vitamin D supplement use and its effect on 25(OH)D levels according to BMI status among US adults. Methods The present analysis was based on data from the National Health and Nutrition Examination Survey (NHANES) cycles 2011-2012 through 2013-2014. The prevalence of vitamin D supplement use according to BMI status among subjects aged 20 years and older by selected characteristics was analyzed. Logistic regression models were assembled to examine the independent association of BMI status and vitamin D supplement use. Similarly, general linear models were used to assess the effect of daily vitamin D supplementation doses (<400 IU, 400-800 IU, and >800 IU) on 25(OH)D concentrations according to BMI status. Results Of 10,076 participants with a mean age of 47.2 [standard error (SE): 0.4] years, 57.5% (SE: 1.7) of normal-weight and 63.5% (SE: 0.9) of obese subjects reported not taking vitamin D supplements over the previous 30 days. After adjustment for potential confounders, obese subjects were 1.3 times more likely to be nonusers of vitamin D supplements and were 24% less likely to take vitamin D supplements ≥400 IU/day compared with their normal-weight counterparts. In addition, significant differences in mean 25(OH)D levels of vitamin D supplementation doses were consistently seen across BMI categories. Indeed, obese and overweight participants taking >800 IU/day of vitamin D supplements had 15.5 and 8.1 nmol/L lower mean concentrations of 25(OH)D than their normal-weight counterparts on average, respectively. Conclusion Obese subjects had a lower prevalence of vitamin D supplement use compared with their normal-weight counterparts. This nutritional disparity may also contribute to low 25(OH)D concentrations seen in obesity. However, a daily vitamin D supplement intake between 400 IU and 800 IU appears to be adequate among obese subjects to achieve optimal 25(OH) levels.

Keywords: obesity; supplements; vitamin d.

Figure 1. 25(OH)D concentrations according to age groups and BMI status

Figure 2. The effect of vitamin D supplements on 25(OH)D concentrations according to BMI status