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. 2017 Dec 6:11:7-9.
doi: 10.1016/j.jctube.2017.12.002. eCollection 2018 May.

Usage of Cartridge Based Nucleic Acid Amplification Test (CB-NAAT/GeneXpert) test as diagnostic modality for pediatric tuberculosis; case series from Mangalore, South India

K S Sahana  1 , Anitha S Prabhu  1 , Prakash Rm Saldanha  1
Affiliations

Usage of Cartridge Based Nucleic Acid Amplification Test (CB-NAAT/GeneXpert) test as diagnostic modality for pediatric tuberculosis; case series from Mangalore, South India

K S Sahana et al. J Clin Tuberc Other Mycobact Dis. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] J Clin Tuberc Other Mycobact Dis. 2020 Sep 9;21:100177. doi: 10.1016/j.jctube.2020.100177. eCollection 2020 Dec. J Clin Tuberc Other Mycobact Dis. 2020. PMID: 32964144 Free PMC article.

Abstract

Background: Diagnosis of Tuberculosis in children is challenging. Hereby we report a case series of 4 patients where Cartridge Based Nucleic Acid Amplification Test (CB NAAT) helped us in early diagnosis.

Case characteristics: Case 1 was a 14-year old girl who was on anti-tuberculous therapy (ATT) for 2 months without any improvement; sputum CBNAAT detected multi-drug resistant tuberculosis (MDR-TB). Case 2 was a 9-year old boy with history and examination findings suggestive of meningitis; CB-NAAT of the cerebrospinal fluid (CSF) was positive. Case 3 was a 1-year old child having fever, cough of 1 month duration with Mantoux positive. CB-NAAT of gastric lavage was positive. Case 4 was a 3- month old child who presented with severe respiratory distress of 11 days duration. Chest x-ray showed miliary mottling; CB-NAAT of gastric lavage was positive.

Conclusion: CB-NAAT testing was very useful in making an early and definitive diagnosis of tuberculosis, including MDR-TB.

Keywords: CB-NAAT; GeneXpert; Pediatric; Tuberculosis.

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Figures

Fig 1
Fig. 1
Case 1. CT chest showing the Consolidation with breakdown cavitations of apico-posterior lobe in right lung, areas of consolidation with cavitation interspersed left lung, multiple centric lobar nodules with tree in bud appearance, multiple pre & para tracheal lymph nodes.
Fig 2
Fig. 2
Case 2. Chest x-ray showing bilateral miliary mottling.
See this image and copyright information in PMC

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