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. 2018 Mar 14:11:17-21.
doi: 10.1016/j.jctube.2018.02.002. eCollection 2018 May.

Change in lung function in never-smokers with nontuberculous mycobacterial lung disease: A retrospective study

Takehiko Kobayashi  1 , Kazunari Tsuyuguchi  2 , Toru Arai  3 , Taisuke Tsuji  1 , Toshiya Maekura  1 , Yu Kurahara  1 , Chikatoshi Sugimoto  3 , Shojiro Minomo  1 , Keiko Nakao  1 , Sayoko Tokura  1 , Yumiko Sasaki  1   2 , Seiji Hayashi  1 , Yoshikazu Inoue  3 , Katsuhiro Suzuki  1
Affiliations

Change in lung function in never-smokers with nontuberculous mycobacterial lung disease: A retrospective study

Takehiko Kobayashi et al. J Clin Tuberc Other Mycobact Dis. .

Abstract

Purpose: Never-smokers account for a large proportion of subjects in general population studies on nontuberculous mycobacteria lung disease (NTM-LD). However, the influence of NTM infection on the lung function of never-smokers has not yet been evaluated. The aim of this study was to determine how NTM-LD impairs the lung function in never-smokers, and whether there are an association between successful NTM-LD treatment in radiologic outcomes and improvement in lung function of never-smokers with NTM-LD or not.

Methods: We performed a retrospective study of patients (1) who have never smoked during their lifetime; (2) with at least two respiratory specimens from sputum, one bronchial washing sample, or one lung tissue that were culture positive for the same NTM species; and (3) who underwent at least two pulmonary function tests. We enrolled healthy never-smokers as the control group.

Results: In 22 never-smokers with NTM-LD, the median forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) at baseline was lower than those in 9 healthy never-smokers [1800 vs 2080 ml (p = 0.23) and 2230 vs 2620 ml (p = 0.06)], respectively. The median change in FEV1 in never-smokers with NTM-LD was lower than that in healthy never-smokers [-70 vs 20 ml per year (p = 0.07), respectively]. On univariate analysis, baseline %-predicted FEV1 in never-smokers with NTM-LD was associated with changes in FVC (p = 0.026) and FEV1 (p = 0.013). Anti-NTM treatment was administered for at least 1 year in 19 patients (86.4%). The relationship between worsening chest CT findings and rapid progressive decline in both FVC (p = 0.66) and FEV1 (p = 0.23) were not significant.

Conclusion: Never-smokers with NTM-LD showed lung function decline. There was no association between successful NTM-LD treatment in radiologic outcomes and improvement in lung function of never-smokers.

Keywords: Bronchiectasis; Lung function; Never-smoker; Nontuberculous mycobacterial lung disease.

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Figures

Fig 1
Fig. 1
Annual change in FVC and FEV1.
See this image and copyright information in PMC

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