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. 2019 Jun 5:16:100107.
doi: 10.1016/j.jctube.2019.100107. eCollection 2019 Aug.

Plasma levels of CRP, neopterin and IP-10 in HIV-infected individuals with and without pulmonary tuberculosis

Fausto Ciccacci  1 , Marco Floridia  2 , Roberta Bernardini  3 , Zita Sidumo  4 , Remigio Josè Mugunhe  5 , Mauro Andreotti  2 , Alfeu Passanduca  4 , Noorjehan Abdul Magid  4 , Stefano Orlando  1 , Maurizio Mattei  3   6 , Marina Giuliano  2 , Sandro Mancinelli  1 , Maria Cristina Marazzi  7 , Leonardo Palombi  1
Affiliations

Plasma levels of CRP, neopterin and IP-10 in HIV-infected individuals with and without pulmonary tuberculosis

Fausto Ciccacci et al. J Clin Tuberc Other Mycobact Dis. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] J Clin Tuberc Other Mycobact Dis. 2020 Sep 9;21:100177. doi: 10.1016/j.jctube.2020.100177. eCollection 2020 Dec. J Clin Tuberc Other Mycobact Dis. 2020. PMID: 32964144 Free PMC article.

Abstract

Introduction: Tuberculosis (TB) is a major cause of morbidity and death worldwide, and disproportionally affects people with HIV. Many cases still remain undiagnosed, and rapid and effective screening strategies are needed to control the TB epidemics. Immunological biomarkers may contribute.

Methods: Plasma samples from healthy individuals (n: 12) and from HIV-infected individuals with (n: 21) and without pulmonary TB (n: 122) were tested for C-reactive protein (CRP), neopterin, and interferon-gamma-inducible protein-10 (IP-10). Increased levels of biomarkers and WHO 4-symptom-screening were compared with the presence of pulmonary TB. Survival status at 12 months was recorded. Associations with CD4 count, BMI, haemoglobin, disease severity, and mortality were analysed.

Results: The plasma levels of the biomarkers were significantly higher in TB-positive (n:21) compared to TB-negative (n:122) subjects. WHO symptoms, increased neopterin (>10 nmol/L) and CRP (>10 mg/L) showed similar sensitivity and different specificity, with increased CRP showing higher and increased neopterin lower specificity. The three markers were inversely correlated to haemoglobin and to CD4, and CRP levels inversely correlated to BMI. The markers were also significantly higher in individuals with subsequent mortality and in individuals with higher mycobacterial load in sputum according to Xpert results (IP-10 and CRP).

Conclusion: This study showed significant associations of the biomarkers analysed with TB infection and mortality, that could have potential clinical relevance. Biomarker levels may be included in operational research on TB screening and diagnosis.

Keywords: Africa; Biomarkers; Diagnosis; Mozambique; Tuberculosis.

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References

    1. UNAIDS. Fact sheet November 2016, Global HIV Statistics; 2016. Available at: http://www.unaids.org/en/resources/fact-sheet. Accessed April 4, 2017.
    1. WHO. Global Tuberculosis Report 2018; 2018. Available at: http://www.who.int/tb/publications/global_report/en/. Accessed November 4, 2018.
    1. Ford N, Matteelli A, Shubber Z. TB as a cause of hospitalization and in-hospital mortality among people living with HIV worldwide: a systematic review and meta-analysis. J Int AIDS Soc. 2016;19(1):20714. - PMC - PubMed
    1. Burki T.K. The global cost of tuberculosis. Lancet Respir Med. 2018;6:13. doi: 10.1016/S2213-2600(17)30468-X. - DOI - PubMed
    1. Steingart K.R., Schiller I., Horne D.J., Pai M., Boehme C.C., Dendukuri N. Xpert(R) MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2014;1:33–36. - PMC - PubMed

    2. CD009593