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. 2020 Mar 1;126(5):1090-1101.
doi: 10.1002/cncr.32583. Epub 2019 Nov 13.

Rising incidence of late-stage head and neck cancer in the United States

Adam Thompson-Harvey  1 , Mahi Yetukuri  2 , Alec R Hansen  2 , Matthew C Simpson  3 , Eric Adjei Boakye  4 , Mark A Varvares  5 , Nosayaba Osazuwa-Peters  3   6
Affiliations
Free article

Rising incidence of late-stage head and neck cancer in the United States

Adam Thompson-Harvey et al. Cancer. .
Free article

Abstract

Background: The current study was conducted to determine whether the incidence of late-stage head and neck cancer (HNC) is decreasing and to estimate the risk of late-stage HNC diagnosis based on race and sex.

Methods: Age-adjusted incidence rates for patients aged ≥18 years with stage IV HNC were abstracted from the Surveillance, Epidemiology, and End Results database (2004-2015). Rates were stratified by race, sex, and age. Joinpoint regression estimated annual percent changes (APCs) in rates over time, and logistic regression estimated adjusted odds ratios (aORs).

Results: There were 57,118 patients with stage IV HNC in the current study cohort, with an average age of 61.9 years. From 2004 to 2015, the age-adjusted incidence rates for stage IV HNC significantly increased by 26.1% (6.11 per 100,000 person-years in 2004 to 7.70 per 100,000 person-years in 2015). White and Asian/Pacific Islander/American Indian/Alaska Native patients had significant increases in incidence (APC for white patients, 3.03 [P < .01] and APC for other races, 1.95 [P < .01]), whereas rates among black patients remained stable but were highest across racial groups. Incidence was higher among males compared with females. When restricted only to patients with stage IVC (metastatic) HNC, there remained a significant increase in incidence, especially for oropharyngeal cancer, which showed a 22.9% increase (0.21 per 100,000 person-years in 2004 vs 0.25 per 100,000 person-years in 2015). Despite a decreasing overall incidence of stage IV HNC in black patients (aOR, 1.28; 95% CI, 1.22-1.34) they, along with males (aOR, 3.95; 95% CI, 3.80-4.11), had significantly increased risks of being diagnosed with late-stage HNC.

Conclusions: There is an increasing incidence of late-stage HNC in the United States, with male patients and black individuals faring the worst.

Keywords: Epidemiology; Joinpoint regression analysis; Surveillance; and End Results (SEER); annual percent change (APC); head and neck cancer (HNC); incidence trends; late-stage presentation.

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References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7-34.
    1. US Department of Health and Human Services. Healthy People 2020 Topics and Objectives: oral health. Accessed April 15, 2019. https://www.healthypeople.gov/node/3511/data-details
    1. Goy J, Hall SF, Feldman-Stewart D, Groome PA. Diagnostic delay and disease stage in head and neck cancer: a systematic review. Laryngoscope. 2009;119:889-898.
    1. Weatherspoon DJ, Chattopadhyay A, Boroumand S, Garcia I. Oral cavity and oropharyngeal cancer incidence trends and disparities in the United States: 2000-2010. Cancer Epidemiol. 2015;39:497-504.
    1. Chaturvedi AK, Engels EA, Pfeiffer RM, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29:4294-4301.

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