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Review
. 2019 Nov 13;132(21):jcs222570.
doi: 10.1242/jcs.222570.

Nutrient regulation of mTORC1 at a glance

Kendall J Condon  1   2   3   4 , David M Sabatini  5   2   3   4
Affiliations
Review

Nutrient regulation of mTORC1 at a glance

Kendall J Condon et al. J Cell Sci. .

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental and intracellular cues to control eukaryotic cell growth. As a pivot point between anabolic and catabolic processes, mTOR complex 1 (mTORC1) signaling has established roles in regulating metabolism, translation and autophagy. Hyperactivity of the mTOR pathway is associated with numerous human diseases, including diabetes, cancer and epilepsy. Pharmacological inhibition of the mTOR pathway can extend lifespan in a variety of model organisms. Given its broad control of essential cellular processes and clear relevance to human health, there is extensive interest in elucidating how upstream inputs regulate mTORC1 activation. In this Cell Science at a Glance article and accompanying poster, we summarize our understanding of how extracellular and intracellular signals feed into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis.

Keywords: Amino acids; Autophagy; Cell growth; Glucose; Lysosome; Nutrients; Signaling; mTORC1.

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Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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