Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Nov 5:13:1179554919886587.
doi: 10.1177/1179554919886587. eCollection 2019.

Adenosquamous Carcinoma of the Pancreas

Hélène Del Arco  1 , Camille Chakiba-Brugère  1 , Laura Salabert  1 , Dominique Béchade  1
Affiliations
Case Reports

Adenosquamous Carcinoma of the Pancreas

Hélène Del Arco et al. Clin Med Insights Oncol. .

Abstract

A 60-year-old woman presented to hospital with abdominal pain and massive weight loss. Imaging studies confirmed the presence of a tumor of the pancreas. Histologic analysis of the sampling performed by echoendoscopic ultrasound fine-needle aspiration found aspects evocative of adenosquamous carcinoma. This case report highlights the difficulties of clinical pathologic diagnosis for these occasionally composite tumors. The patient underwent palliative chemotherapy based on platinum and 5-fluorouracil, followed by second-line chemotherapy with FOLFIRI after progression. Adenosquamous carcinoma of the pancreas remains a rare tumor with very poor prognosis and limited therapeutic options.

Keywords: PET scan; adenosquamous cell carcinoma; core needle biopsy; endoscopic ultrasound; pancreatic cancer.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Locally advanced organ involvement of the pancreatic tail.
Figure 2.
Figure 2.
Endoscopic ultrasound showing a 5.3 × 4 cm anechoic cystic lesion with an irregularly thick wall and multiple mural nodules in the pancreatic tail.
Figure 3.
Figure 3.
Immunohistochemistry showing a positive expression of CK7.
Figure 4.
Figure 4.
Immunohistochemistry showing a positive expression of P40.
Figure 5.
Figure 5.
Immunohistochemistry showing that the tumor cells were negative for CDX2.
Figure 6.
Figure 6.
Tumor hyperfixation with PET scanner. PET indicates positron emission tomography.
See this image and copyright information in PMC

References

    1. Boyd CA, Benarroch-Gampel J, Sheffield KM, Cooksley CD, Riall TS. 415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival. J Surg Res. 2012;174:12-19. - PMC - PubMed
    1. Katz MHG, Taylor TH, Al-Refaie WB, et al. Adenosquamous versus adenocarcinoma of the pancreas: a population-based outcomes analysis. J Gastrointest Surg. 2011;15:165-174. - PMC - PubMed
    1. Borazanci E, Millis SZ, Korn R, et al. Adenosquamous carcinoma of the pancreas: molecular characterization of 23 patients along with a literature review. World J Gastrointest Oncol. 2015;7:132-140. - PMC - PubMed
    1. Simone CG, Zuluaga Toro T, Chan E, Feely MM, Trevino JG, George TJ., Jr. Characteristics and outcomes of adenosquamous carcinoma of the pancreas. Gastrointest Cancer Res. 2013;6:75-79. - PMC - PubMed
    1. Pour PM, Sayed S, Sayed G. Hyperplastic, preneoplastic and neoplastic lesions found in 83 human pancreases. Am J Clin Pathol. 1982;77:137-152. - PubMed

Publication types

LinkOut - more resources