The Need for a Consensus Next-generation Sequencing Panel for Mature Lymphoid Malignancies

Abstract

Supplemental Digital Content is available in the text.

Figure 1

A heatmap representation of the prevalence of gene alterations in mature B lymphoid malignancies from the LYSA/GBMHM consensus panel. The ∗ symbol for CDKN2A underlines that this locus is altered by deletions (and not mutations). The borders of the squares are colored when the alteration has a clear clinical impact in a particular lymphoma subtype (diagnostic in yellow, prognostic in red, and theranostic in blue). ABC = activated B cell, BL = Burkitt lymphoma, CLL = chronic lymphocytic leukemia, DLBLCL = diffuse large B cell lymphoma, FL = follicular lymphoma, GC = germinal center, HCL = hairy cell lymphoma, HL = Hodgkin lymphoma, MCL = mantle cell lymphoma, MZL = marginal zone lymphoma, PCNSL = primary central nervous system lymphoma, PMBCL = primary mediastinal B cell lymphoma, WM = Waldenström macroglobulinemia.

Figure 2

A heatmap representation of the prevalence of gene mutations in mature T lymphoid malignancies from the LYSA/GBMHM consensus panel. The borders of the squares are colored when the alteration has a clinical impact in a particular lymphoma subtype (diagnostic in yellow, theranostic in blue). AITL = angio-immunoblastic T lymphoma, ALCL = anaplastic large cell lymphoma, ATLL = adult T leukemia/lymphoma, EATL = enteropathy associated T lymphoma, HSTL = hepatosplenic T lymphoma, LGL = large granular lymphocytic leukemia, MEITL = monomorphic epitheliotropic intestinal T lymphoma, NKTCL = nasal type NK/T cell lymphoma, PTCL-NOS = peripheral T cell lymphoma, not otherwise specified, PTCL-TFH = nodal peripheral T cell lymphoma derived from T_FH cells, Sezary = Sezary syndrome, T-PLL = T-prolymphocytic leukemia.