Chronotherapy for hypertension: improvement in patient outcomes with bedtime administration of antihypertensive drugs

Affiliations

Editorial

Pankaj Mathur et al. Eur Heart J. 2020.

. 2020 Dec 21;41(48):4577-4579.

doi: 10.1093/eurheartj/ehz836.

¹ Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.

No abstract available

Comment in

Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project.
Kreutz R, Kjeldsen SE, Burnier M, Narkiewicz K, Oparil S, Mancia G. Kreutz R, et al. Blood Press. 2020 Jun;29(3):135-136. doi: 10.1080/08037051.2020.1747696. Epub 2020 Apr 27. Blood Press. 2020. PMID: 32338542 No abstract available.

Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial.
Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Fernández JR, Mojón A, Ayala DE; Hygia Project Investigators. Hermida RC, et al. Eur Heart J. 2020 Dec 21;41(48):4565-4576. doi: 10.1093/eurheartj/ehz754. Eur Heart J. 2020. PMID: 31641769 Clinical Trial.