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. 2020 Jun;28(6):2761-2768.
doi: 10.1007/s00520-019-05122-3. Epub 2019 Nov 14.

Late complications associated with totally implantable venous access port implantation via the internal jugular vein

Shigeaki Tsuruta  1 , Yasutomo Goto  1 , Hideo Miyake  1 , Hidemasa Nagai  1 , Yuichiro Yoshioka  1 , Norihiro Yuasa  2 , Junichi Takamizawa  3
Affiliations

Late complications associated with totally implantable venous access port implantation via the internal jugular vein

Shigeaki Tsuruta et al. Support Care Cancer. 2020 Jun.

Abstract

Purpose: Several studies have analyzed late complications associated with totally implantable venous access ports (TIVAP) implantation via the internal jugular vein (IJV); however, the reported results are inconclusive. The aim of the study is to elucidate the characteristics and risk factors of late complications associated with TIVAP implantation via the IJV.

Methods: The study included 482 patients who underwent TIVAP implantation for long-term chemotherapy and/or nutritional support between April 2012 and December 2017. Most patients (95.2%) had malignant diseases. Events requiring TIVAP removal were defined as TIVAP-related complications.

Results: The median TIVAP and global follow-ups were 319 days (IQR 152-661) and 218,971 catheter days, respectively. The 3-year cumulative TIVAP availability rate was 70%. There were 44 complications (incidence of 9.1%; 0.201 complications/1000 catheter days). Infectious, catheter-related, and port-related complications occurred in 21, 14, and 9 patients, respectively with infectious complications occurring earlier and more frequently than catheter- and port-related complications. Multivariate analysis revealed that age < 65 years and presence of non-gastrointestinal diseases were significant unfavorable factors for TIVAP-related complications. Patients with 1 and 2 of these factors had an elevated risk (2.2 and 5.4 times, respectively) compared with those without.

Conclusions: Among the late complications associated with TIVAP implantation via the IJV, infectious complications occur earlier and more frequently than catheter- and port-related complications. Patients with an age < 65 years and having non-gastrointestinal diseases have a significantly high risk of TIVAP-related complications.

Keywords: Complication; Infection; Internal jugular vein; Totally implantable venous access port.

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