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Review

Simulating the Effect of 200 kHz AC Electric Fields on Tumour Cell Structures to Uncover the Mechanism of a Cancer Therapy

Kristen W. Carlson  1 , Jack A. Tuszynski  2 , Socrates Dokos  3 , Nirmal Paudel  4 , Ze’ev Bomzon  5
Sergey Makarov  1 , Marc Horner  2 , Gregory Noetscher  3
, editors.
In: Brain and Human Body Modeling: Computational Human Modeling at EMBC 2018 [Internet]. Cham (CH): Springer; 2019. Chapter 6.
.
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Review

Simulating the Effect of 200 kHz AC Electric Fields on Tumour Cell Structures to Uncover the Mechanism of a Cancer Therapy

Kristen W. Carlson et al.
Free Books & Documents

Excerpt

Our goal is to uncover the mechanism underlying tumour-treating fields’ efficacy in killing cancer cells. Modelling the effects of these 200 kHz alternating current electric fields on tumour cell sub-structures has led us to focus on the microtubules (MTs), C-termini and the motor protein kinesin, which are integral to the critical functions of MT transport of proteins during the delicate orchestration of cell division (mitosis). Leading hypotheses of the TTFields’ mechanism that we are modelling include disruption of mitosis functions (such as the ‘kinesin walk’ along MTs), C-termini state transitions and MT polymerization.

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References

    1. Kirson, E. D., et al. (2004). Disruption of cancer cell replication by alternating electric fields. Cancer Research, 64, 3288–3295. - PubMed
    1. Kirson, E. D., et al. (2007). Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proceedings of the National Academy of Sciences of the United States of America, 104, 10152–10157. - PMC - PubMed
    1. Mun, E.J., et al. (2018) Tumor-treating fields: A fourth modality in cancer treatment. Clin Cancer Research, 24(2), 266–275. - PubMed
    1. Novocure Ltd. (2018). https://www.novocure.com/our-pipeline/. Accessed 23 Oct 2018.
    1. Priel, A., et al. (2005). Transitions in microtubule C-termini conformations as a possible dendritic signaling phenomenon. European Biophysics Journal, 35, 40–52. - PubMed

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