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In: Brain and Human Body Modeling: Computational Human Modeling at EMBC 2018 [Internet]. Cham (CH): Springer; 2019. Chapter 4.
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Affiliations
Affiliations
1 Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
2 Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
3 Department of Psychiatry, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
4 Feil Family Brain and Mind Research Institute, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
5 Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
6 Institute of Geriatric Psychiatry, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
7 Department of Psychiatry, University of Amsterdam, Amsterdam, Netherlands
8 Department of Psychiatry, Rijnstate Hospital, Arnhem, Netherlands
Book Affiliations
1 Massachusetts General Hospital, Boston, MA, USA
2 ANSYS, Inc., Evanston, IL, USA
3 Worcester Polytechnic Institute, Worcester, MA, USA
1 Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
2 Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
3 Department of Psychiatry, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
4 Feil Family Brain and Mind Research Institute, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
5 Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
6 Institute of Geriatric Psychiatry, Weill Cornell Medical College–New York Presbyterian Hospital, New York, NY, USA
7 Department of Psychiatry, University of Amsterdam, Amsterdam, Netherlands
8 Department of Psychiatry, Rijnstate Hospital, Arnhem, Netherlands
Book Affiliations
1 Massachusetts General Hospital, Boston, MA, USA
2 ANSYS, Inc., Evanston, IL, USA
3 Worcester Polytechnic Institute, Worcester, MA, USA
Major depressive disorder (MDD) is a highly prevalent condition and present first-line treatment options are inadequate. Among nonpharmacological treatment alternatives, noninvasive brain stimulation shows tremendous promise. There are two approved brain stimulation techniques for the treatment of MDD: electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS). The goal of this study is to quantify the induced electric field (E-field) at the dorsolateral prefrontal cortex (DLPFC) in a group of depressed patients. This study aimed to characterize the induced electric field distributions in a population of patients who received bilateral and/or unilateral electroconvulsive therapy and in a group of patients who received rTMS for the treatment of depression. We also investigated an alternative magnetic stimulation approach, using rotating permanent magnets.
Ferrari, A. J., et al. (2013). Burden of depressive disorders by country, sex, age, and year: Findings from the global burden of disease study 2010. PLoS Medicine, 10(11), e1001547.
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Stone, D. M., et al. (2018). Vital signs: Trends in state suicide rates — United States, 1999–2016 and circumstances contributing to suicide — 27 states, 2015. MMWR. Morbidity and Mortality Weekly Report, 67(22), 617–624.
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Rush, A. J., et al. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR∗D report, (in eng). The American Journal of Psychiatry, 163(11), 1905–1917.
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Husain, M. M., et al. (2004). Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT): A Consortium for Research in ECT (CORE) report. The Journal of Clinical Psychiatry, 65(4), 485–491.
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Phillips, J. W., & Jin, Y. (2013). Devices and methods of low frequency magnetic stimulation therapy. USA.