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. 2020 Mar;26(3):553-561.
doi: 10.1016/j.bbmt.2019.11.003. Epub 2019 Nov 11.

Predictors of Loss to Follow-Up Among Pediatric and Adult Hematopoietic Cell Transplantation Survivors: A Report from the Center for International Blood and Marrow Transplant Research

David Buchbinder  1 , Ruta Brazauskas  2 , Khalid Bo-Subait  2 , Karen Ballen  3 , Susan Parsons  4 , Tami John  5 , Theresa Hahn  6 , Akshay Sharma  7 , Amir Steinberg  8 , Anita D'Souza  2 , Anita J Kumar  4 , Ayami Yoshimi  9 , Baldeep Wirk  10 , Bronwen Shaw  2 , César Freytes  11 , Charles LeMaistre  12 , Christopher Bredeson  13 , Christopher Dandoy  14 , David Almaguer  15 , David I Marks  16 , David Szwajcer  17 , Gregory Hale  18 , Harry Schouten  19 , Hasan Hashem  20 , Hélène Schoemans  21 , Hemant S Murthy  22 , Hillard M Lazarus  23 , Jan Cerny  24 , Jason Tay  25 , Jean A Yared  26 , Kehinde Adekola  27 , Kirk R Schultz  28 , Leslie Lehmann  29 , Linda Burns  30 , Mahmoud Aljurf  31 , Miguel Angel Diaz  32 , Navneet Majhail  33 , Nosha Farhadfar  34 , Rammurti Kamble  35 , Richard Olsson  36 , Raquel Schears  37 , Sachiko Seo  38 , Sara Beattie  39 , Saurabh Chhabra  2 , Bipin N Savani  40 , Sherif Badawy  41 , Siddhartha Ganguly  42 , Stefan Ciurea  43 , Susana Marino  44 , Usama Gergis  45 , Yachiyo Kuwatsuka  46 , Yoshihiro Inamoto  47 , Nandita Khera  48 , Shahrukh Hashmi  49 , William Wood  50 , Wael Saber  2
Affiliations

Predictors of Loss to Follow-Up Among Pediatric and Adult Hematopoietic Cell Transplantation Survivors: A Report from the Center for International Blood and Marrow Transplant Research

David Buchbinder et al. Biol Blood Marrow Transplant. 2020 Mar.

Abstract

Follow-up is integral for hematopoietic cell transplantation (HCT) care to ensure surveillance and intervention for complications. We characterized the incidence of and predictors for being lost to follow-up. Two-year survivors of first allogeneic HCT (10,367 adults and 3865 children) or autologous HCT (7291 adults and 467 children) for malignant/nonmalignant disorders between 2002 and 2013 reported to the Center for International Blood and Marrow Transplant Research were selected. The cumulative incidence of being lost to follow-up (defined as having missed 2 consecutive follow-up reporting periods) was calculated. Marginal Cox models (adjusted for center effect) were fit to evaluate predictors. The 10-year cumulative incidence of being lost to follow-up was 13% (95% confidence interval [CI], 12% to 14%) in adult allogeneic HCT survivors, 15% (95% CI, 14% to 16%) in adult autologous HCT survivors, 25% (95% CI, 24% to 27%) in pediatric allogeneic HCT survivors, and 24% (95% CI, 20% to 29%) in pediatric autologous HCT survivors. Factors associated with being lost to follow-up include younger age, nonmalignant disease, public/no insurance (reference: private), residence farther from the tranplantation center, and being unmarried in adult allogeneic HCT survivors; older age and testicular/germ cell tumor (reference: non-Hodgkin lymphoma) in adult autologous HCT survivors; older age, public/no insurance (reference: private), and nonmalignant disease in pediatric allogeneic HCT survivors; and older age in pediatric autologous HCT survivors. Follow-up focusing on minimizing attrition in high-risk groups is needed to ensure surveillance for late effects.

Keywords: Bone marrow transplantation; Lost to follow-up; Stem cell transplantation; Survivor.

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Conflict of interest statement

Conflict of Interest Disclosure

Dr. Ganguly receives support from Seattle Genetics, Kite Phrama, Janssen Pharmaceuticals, and Daiichi Sankyo.

Figures

Figure 1:
Figure 1:
Among 2-year survivors, the cumulative incidence of becoming lost to follow-up by age at the time of transplantation (adult versus pediatric) and by type of transplant (allogeneic versus autologous).
See this image and copyright information in PMC

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