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. 2019 Oct 16;8(3):129-136.
doi: 10.4103/jrpp.JRPP_18_71. eCollection 2019 Jul-Sep.

Clinical Features, Treatment, Prognosis, and Mortality in Paraquat Poisonings: A Hospital-Based Study in Iran

Zohreh Oghabian  1 , June Williams  2 , Mohammad Mohajeri  3 , Samaneh Nakhaee  4 , Saeedeh Shojaeepour  5 , Alireza Amirabadizadeh  4 , Samira Elhamirad  6 , Morteza Hajihosseini  7 , Borhan Mansouri  8 , Omid Mehrpour  4
Affiliations

Clinical Features, Treatment, Prognosis, and Mortality in Paraquat Poisonings: A Hospital-Based Study in Iran

Zohreh Oghabian et al. J Res Pharm Pract. .

Erratum in

Abstract

Objective: The aim of the present study was to evaluate the demographics, clinical characteristics, fatal dose, the efficacy of treatments, and prognosis in paraquat (PQ) poisoning in the Kerman Province of Iran.

Methods: This analytical cross-sectional study was conducted on 126 PQ poisoned patients who were referred to Afzalipour Hospital during 2006-2015. Demographic variables such as age and gender, signs and symptoms of poisoning, the estimated ingested dosage of PQ, and clinical outcome were extracted from medical records. Patients were compared and categorized into two groups considering the outcome: survivors and nonsurvivors. Patients with nonoral exposures, combined drug exposures, PQ exposures more than 24 h before the presentation, and critical underlying diseases were not included in the study.

Findings: Our results indicated that the mean dose of PQ used by all patients was 2358 mg, which was reported as 1846 and 2812 mg in females and males, respectively. Moreover, the results showed that the highest mortality rate was in patients with respiratory distress, followed by oral ulceration and excess salivation. In all PQ-poisoned patients, the dose of greater than approximately 2250 mg predicted death with 86.2% specificity and 75.7% sensitivity.

Conclusion: Based on the results of the present study, the mortality rate in PQ-poisoned patients depended on the dose of poison, blood sugar level, and aspartate transaminase levels. Our results suggest that these parameters have excellent prognostic value for the prediction of mortality.

Keywords: Mortality; paraquat; poisoning; prediction; prognosis; survival; treatment.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study patients
Figure 2
Figure 2
Distribution of treatment methods with outcome categories (a) and distribution of symptoms relative to outcome categories (b); APA: Abnormal Pulmonary Auscultation, EEE: Esophageal Erythema Erosion, GEE: Gastric Erythema Erosion, DI: Duodenal Involvement; Frequency = number of patients, with total n=126
See this image and copyright information in PMC

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