Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr;47(4):409-413.
doi: 10.1111/cup.13614. Epub 2019 Nov 28.

Trichoblastic carcinosarcoma: A case report and literature review

Caroline I M Underwood  1 , Parisa Mansoori  1 , Angelica M Selim  1 , Rami N Al-Rohil  1
Affiliations
Review

Trichoblastic carcinosarcoma: A case report and literature review

Caroline I M Underwood et al. J Cutan Pathol. 2020 Apr.

Abstract

Trichoblastic carcinosarcoma is a rare biphasic adnexal neoplasm. This case report chronicals the eighth occurrence of this tumor published in the English literature and provides a review of the prior publications. Clinically, this tumor presents as an isolated, rapidly growing lesion in elderly patients and is usually cured by complete surgical excision, with no evidence of recurrence or metastasis at follow-up (7/8 cases). Histopathologically, trichoblastic carcinosarcoma is dermal-based, with an epithelial component of basal cells and a mesenchymal component of spindle cells, both of which display malignant features. In addition to a morphologic description of trichoblastic carcinosarcoma, a discussion of the differential diagnoses, including other biphasic neoplasms, is also included. The small number of cases of trichoblastic carcinosarcoma is most likely secondary to under-recognition and underreporting and a larger case volume is needed to more accurately assess the clinical course and treatment strategies.

Keywords: cutaneous carcinosarcoma; malignant adnexal neoplasm; trichoblastic carcinosarcoma.

PubMed Disclaimer

References

REFERENCES

    1. Elder DE, Massi D, Scolyer RA, Willemze R. WHO Classification of Skin Tumours. International Agency for Research on Cancer; 2018.
    1. Regauer S, Beham-Schmid C, Okcu M, Hartner E, Mannweiler S. Trichoblastic carcinoma ("malignant trichoblastoma") with lymphatic and hematogenous metastases. Mod Pathol. 2000;13(6):673-678.
    1. Kazakov DV, Kempf W, Michal M. Low-grade trichoblastic carcinosarcoma of the skin. Am J Dermatopathol. 2004;26(4):304-309.
    1. Liegl B, Leibl S, Okcu M, Beham-Schmid C, Regauer S. Malignant transformation within benign adnexal skin tumours. Histopathology. 2004;45(2):162-170.
    1. Kazakov DV, Vittay G, Michal M, Calonje E. High-grade trichoblastic carcinosarcoma. Am J Dermatopathol. 2008;30(1):62-64.

LinkOut - more resources