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. 2019 Dec 4;141(48):18926-18931.
doi: 10.1021/jacs.9b08415. Epub 2019 Nov 19.

Tantalum-Catalyzed Amidation of Amino Acid Homologues

Wataru Muramatsu  1 , Hisashi Yamamoto  1
Affiliations

Tantalum-Catalyzed Amidation of Amino Acid Homologues

Wataru Muramatsu et al. J Am Chem Soc. .

Abstract

A tantalum-catalyzed solvent-free approach for the construction of amide bonds with 1-(trimethylsilyl)imidazole is developed, and the mild reaction conditions are applicable to a wide variety of electrophilic amino acid homologues. This approach delivers a new class of peptides in high yields without any epimerization.

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