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Review
. 2020 Jan;61(1):6-12.
doi: 10.2967/jnumed.119.232330. Epub 2019 Nov 15.

Prostate-Specific Membrane Antigen-Guided Surgery

Tobias Maurer  1   2 , Markus Graefen  3 , Henk van der Poel  4 , Freddie Hamdy  5 , Alberto Briganti  6 , Matthias Eiber  7 , Hans-Jürgen Wester  8 , Fijs W B van Leeuwen  4   9
Affiliations
Free article
Review

Prostate-Specific Membrane Antigen-Guided Surgery

Tobias Maurer et al. J Nucl Med. 2020 Jan.
Free article

Abstract

Since its introduction to the diagnostic pathway for prostate cancer management, prostate-specific membrane antigen (PSMA)-ligand PET has demonstrated great potential. PSMA-ligand imaging is increasingly influencing therapeutic decision making, although its impact on patient outcomes still needs to be defined. One relatively new application, enabled through chemical and engineering efforts, is PSMA-guided surgery. This review highlights the potential of PSMA-guided surgery and discusses its implications in lymph node dissection in primary and recurrent prostate cancer.

Keywords: fluorescence; image-guided surgery; lymph node dissection; prostate cancer; salvage.

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