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Review
. 2020 Jan;36(1):141-153.
doi: 10.1016/j.ccc.2019.08.011. Epub 2019 Oct 21.

Biomarkers and Right Ventricular Dysfunction

Natasha M Pradhan  1 , Christopher Mullin  2 , Hooman D Poor  3
Affiliations
Review

Biomarkers and Right Ventricular Dysfunction

Natasha M Pradhan et al. Crit Care Clin. 2020 Jan.

Abstract

Right ventricular failure is common in critically ill patients, as it frequently results from pulmonary embolism or pulmonary hypertension, and can complicate sepsis and the acute respiratory distress syndrome. Right ventricular dysfunction can be challenging to manage and is associated with poor outcomes in this wide array of disease. Laboratory biomarkers are rapid, noninvasive, accurate, and widely available and thus are useful in the diagnosis and management of right ventricular dysfunction in the critically ill patient. This article discusses the pathophysiology of right ventricular failure and reviews the applications of commonly used biomarkers in right ventricular dysfunction in critical care.

Keywords: Biomarkers; Brain natriuretic peptide; Pulmonary embolism; Pulmonary hypertension; Right ventricular dysfunction; Troponin.

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Figures

Fig. 1
Fig. 1
Pathophysiology of RV failure.
Fig. 2
Fig. 2
Risk stratification of pulmonary embolism.
See this image and copyright information in PMC

References

    1. Konstam M.A., Kiernan M.S., Bernstein D., et al. Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association. Circulation. 2018;137(20):e578–e622. - PubMed
    1. Beckman M.G., Hooper W.C., Critchley S.E., et al. Venous thromboembolism: a public health concern. Am J Prev Med. 2010;38(4):S495–S501. - PubMed
    1. Noordegraaf A.V., Chin K.M., Haddad F., et al. Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update. Eur Respir J. 2019;53(1):1801900. - PMC - PubMed
    1. Zochios V., Parhar K., Tunnicliffe W., et al. The right ventricle in ARDS. Chest. 2017;152(1):181–193. - PubMed
    1. Zapol W.M., Snider M.T. Pulmonary hypertension in severe acute respiratory failure. N Engl J Med. 1977;296(9):476–480. - PubMed

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