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Review
. 2019 Dec;40(12):1149-1162.
doi: 10.1016/j.it.2019.10.006. Epub 2019 Nov 14.

Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

Dinesh Raghu  1 , Hai-Hui Xue  2 , Lisa A Mielke  3
Affiliations
Review

Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

Dinesh Raghu et al. Trends Immunol. 2019 Dec.

Abstract

T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).

Keywords: T cell; T cell factor-1; TCF-1; immunotherapy; innate lymphoid cell; stem cell-like memory; transcription factor.

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