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Case Reports
. 2020 Mar;67(3):729-732.
doi: 10.1007/s12020-019-02132-3. Epub 2019 Nov 16.

HLA DRB1*0415: a new possible genetic susceptibility factor for Hirata's disease

Valeria Cambria  1 , Guglielmo Beccuti  2 , Filippo Gatti  2 , Chiara Bona  2 , Mauro Maccario  2 , Valentina Gasco  2
Affiliations
Free article
Case Reports

HLA DRB1*0415: a new possible genetic susceptibility factor for Hirata's disease

Valeria Cambria et al. Endocrine. 2020 Mar.
Free article

Abstract

Context: Hirata's disease (HD) is a rare autoimmune cause of hypoglycemia. Patients suffering from this condition have a genetic predisposition, determined by HLA DR4, with some differences in the worldwide population. In Caucasians HLA DRB1*0403 is the most frequent susceptibility background on which some drugs play as triggers.

Case description: We reported the case of a woman with several hypoglycemic episodes, characterized by high insulin and c-peptide levels. Biochemical and morphological exams excluded a neuroendocrine tumor. HD was diagnosed according to insulin autoantibodies positivity and patient's history, particularly about drugs taken. The HLA analysis revealed DRB1*0415 allele.

Conclusions: We found a potential new predisposing factor for HD, HLA DRB1*0415 allele, never described before as genetic background to insulin autoimmune syndrome in Caucasians.

Keywords: Alpha-lipoic acid; Hypoglycemia; Insulin autoantibodies; Insulin autoimmune syndrome.

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References

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