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Review
. 2019 Dec;17(6):570-579.
doi: 10.1007/s11914-019-00531-z.

Bone Health in Glomerular Kidney Disease

Dorey A Glenn  1 , Michelle R Denburg  2
Affiliations
Review

Bone Health in Glomerular Kidney Disease

Dorey A Glenn et al. Curr Osteoporos Rep. 2019 Dec.

Abstract

Purpose of review: To summarize the literature regarding alterations in bone health in patients with glomerular kidney disease and highlight areas in need of additional investigation.

Recent findings: There is mounting evidence that children and adults with glomerular conditions, with or without compromised kidney function, comprise a distinct subgroup of patients with unique risk factors for altered bone health. Patients with glomerular kidney disease are exposed to both disease-related and treatment-related factors that affect bone structure and function. In addition to chronic kidney disease-related risk factors for impaired bone health, high rates of exposure to osteotoxic medications, varying degrees of systemic inflammation, and altered vitamin D metabolism may contribute to compromised bone health in individuals with glomerular disease. Further study is needed to better understand these risk factors and the complex interaction between the immune system and bone cells in glomerular disease.

Keywords: Bone; Bone density; Fracture; Glomerular; Vitamin D.

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Conflict of interest statement

Conflict of Interest

Michelle Denburg reports grants from Mallinckrodt, NIDDK, and PCORI, outside the submitted work.

Dorey Glenn declares no conflict of interest.

Figures

Figure 1:
Figure 1:
Conceptual framework depicting potential risk factors for impaired bone mineral density and fracture in glomerular disease.
See this image and copyright information in PMC

References

    1. Webster AC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease. The Lancet. 2017;389:1238–52. - PubMed
    1. Floege J, Amann K. Primary glomerulonephritides. The Lancet. 2016;387:2036–48. - PubMed
    1. Saran R, Robinson B, Abbott KC, Agodoa LYC, Albertus P, Ayanian J, et al. US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis Off J Natl Kidney Found. 2017;69:A7–8. - PMC - PubMed
    1. Minimal Change Nephrotic Syndrome in Children: Deaths During the First 5 to 15 Years’ Observation. Pediatrics. 1984;73:497. - PubMed
    1. Adedoyin O, Frank R, Vento S, Vergara M, Gauthier B, Trachtman H. Cardiac disease in children with primary glomerular disorders—role of focal segmental glomerulosclerosis. Pediatr Nephrol. 2004;19:408–12. - PubMed

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