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Review
. 2020 Jan;15(1):35-43.
doi: 10.1016/j.cpet.2019.08.008. Epub 2019 Oct 29.

Programmed Cell Death-1/Ligand-1 PET Imaging: A Novel Tool to Optimize Immunotherapy?

Sarah R Verhoeff  1 , Michel M van den Heuvel  2 , Carla M L van Herpen  1 , Berber Piet  2 , Erik H J G Aarntzen  3 , Sandra Heskamp  4
Affiliations
Free article
Review

Programmed Cell Death-1/Ligand-1 PET Imaging: A Novel Tool to Optimize Immunotherapy?

Sarah R Verhoeff et al. PET Clin. 2020 Jan.
Free article

Abstract

Clinical indications for immune checkpoint inhibitor (ICI) therapy are rapidly expanding for various stages of several solid tumors. The success of ICIs results from a complex interplay between cancer cells and their immune microenvironment. PD-1/PD-L1 PET imaging enables to study of these interactions in the tumor microenvironment in a clinical setting. These noninvasive, sensitive and quantitative tools may play an important role in optimizing ICI efficacy.

Keywords: Cancer; Checkpoint inhibitors; Immunotherapy; Molecular imaging; PD-1; PD-L1; immunoPET.

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