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Review
. 2019 Dec:46:101332.
doi: 10.1016/j.smim.2019.101332. Epub 2019 Nov 14.

Immunological biomarkers in severe asthma

Dharani Narendra  1 , John Blixt  1 , Nicola A Hanania  2
Affiliations
Review

Immunological biomarkers in severe asthma

Dharani Narendra et al. Semin Immunol. 2019 Dec.

Abstract

Severe asthma is heterogeneous in its clinical presentation, underlying pathophysiology, course and response to therapy. Clinical and physiological assessment of severe asthma is often inadequate in predicting underlying disease mechanisms and or response to medications. With the emergence of novel targeted therapies in severe asthma, the need for reproducible, easily measured biomarkers became obvious but only few are currently available for clinical use. These biomarkers along with the clinical presentation of the patient play an important role in identifying phenotypes and endotypes, predicting the clinical course and prognosis and improving the precision therapeutic approach to asthma.

Keywords: Biomarkers; Composite biomarkers; Eosinophils; Exhaled nitric oxide; IgE; Periostin; Severe asthma; T2 airway inflammation.

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