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Review
. 2020 Feb;72(1-2):85-88.
doi: 10.1007/s00251-019-01141-w. Epub 2019 Nov 18.

Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells

Ludvig M Sollid  1 , Jason A Tye-Din  2 , Shuo-Wang Qiao  3 , Robert P Anderson  2 , Carmen Gianfrani  4 , Frits Koning  5
Affiliations
Review

Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells

Ludvig M Sollid et al. Immunogenetics. 2020 Feb.

Abstract

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4+ T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.

Keywords: Celiac disease; Epitopes; Gluten; HLA-DQ2; HLA-DQ8; T cell.

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