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Review
. 2021 Jan;53(1):281-297.
doi: 10.1111/ejn.14621. Epub 2019 Dec 20.

Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress-related disorders

Enrica Boda  1   2
Affiliations
Free article
Review

Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress-related disorders

Enrica Boda. Eur J Neurosci. 2021 Jan.
Free article

Abstract

Depressive disorders are complex, multifactorial disorders that have been traditionally attributed exclusively to neuronal abnormalities. However, recent studies have increased our understanding of the contribution of glial cells-and particularly of oligodendroglia-to the pathogenesis and treatment outcome of depression and stress-related disorders. This review scrutinizes recent studies focusing on the neurosupportive functions exerted by myelin and oligodendrocyte lineage cells and their disruption in depression and stress-related disorders. It also illustrates how myelin and oligodendroglia respond to antidepressants and non-pharmacological treatment alternatives and proposes oligodendroglia-directed approaches as novel therapeutic options for depressive disorders.

Keywords: antidepressant; early life experience; myelination; neuromodulation.

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References

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