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Review
. 2020 Feb;67(2):e28085.
doi: 10.1002/pbc.28085. Epub 2019 Nov 17.

Risk factors and management of corticosteroid-induced hyperglycaemia in paediatric acute lymphoblastic leukaemia

Kyriacos Gregoriou  1   2 , Ian Craigie  2 , Brenda Gibson  3 , Avril Mason  1   2 , Mohamad Guftar Shaikh  1   2
Affiliations
Review

Risk factors and management of corticosteroid-induced hyperglycaemia in paediatric acute lymphoblastic leukaemia

Kyriacos Gregoriou et al. Pediatr Blood Cancer. 2020 Feb.

Abstract

Corticosteroids are incorporated into protocols for the treatment of acute lymphoblastic leukaemia, and hyperglycaemia is a recognised side effect. Corticosteroids exert their hyperglycaemic effect with a multifactorial mechanism. Complications of hyperglycaemia include an increased risk of infection - bacterial, viral and fungal. Approximately half of the children who develop corticosteroid-associated hyperglycaemia are predicted to require insulin treatment, with age and obesity having found to be predictive factors. Fasting and random glucose values can be used to define hyperglycaemia. This review focuses on the published evidence for significant predictive factors for the development of corticosteroid-induced hyperglycaemia and provides guidance on management.

Keywords: acute lymphoblastic leukaemia; corticosteroids; hyperglycaemia; insulin.

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References

REFERENCES

    1. Kurir TT, Bozic J, Marcotic A, Novak A. New insights in steroid diabetes. Acta Med Croatica. 2012;66(4):303-310.
    1. Puttanna A, Cunningham A, Scanlon J. Hyperglycaemia as a result of stress and possible drug interactions: a case report. Practical Diabetes International. 2010;27(7):304-305.
    1. Hwang J, Weiss R. Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment. Diabetes Metab Res Rev. 2014;30(2):96-102.
    1. University of Birmingham, Cancer Research UK Clinical Trials Unit, Leukaemia and Lymphoma Research, Children's Cancer Trials Team. United Kingdom National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011, UKALL2011. Version 4.0. December 21, 2012.
    1. American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care. 2014;38(Supplement_1):S8-S16.

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