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Review
. 2019 Oct 29:10:1222.
doi: 10.3389/fphar.2019.01222. eCollection 2019.

Isobologram Analysis: A Comprehensive Review of Methodology and Current Research

Ruo-Yue Huang  1 , Linlin Pei  1 , QuanJin Liu  1 , Shiqi Chen  1 , Haibo Dou  1 , Gang Shu  1 , Zhi-Xiang Yuan  1 , Juchun Lin  1 , Guangneng Peng  1 , Wei Zhang  1 , Hualin Fu  1
Affiliations
Review

Isobologram Analysis: A Comprehensive Review of Methodology and Current Research

Ruo-Yue Huang et al. Front Pharmacol. .

Abstract

Drug combination is a common method for clinical disease treatment. Whether the combination of drugs is reasonable often affects the result of the disease treatment. Many methods have been used to evaluate interaction between drugs to date. Isobologram analysis has been mathematically proven and widely used to evaluate drug interactions. In this paper, the principle of isobologram analysis and its application in drug interaction evaluation are summarized. The applications of the similar cotoxicity coefficient and fractional inhibitory concentration index in the evaluation of drug interaction are also reviewed. This work is expected to evaluate the effect of formulations scientifically and provide scientific judgment standards for the development of formulations and clinical drug compatibility.

Keywords: application; drug interaction; isobologram analysis; principle; synergy.

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Figures

Figure 1
Figure 1
Classification of drug interactions. (A) is the classification of drug interactions. (B) is the isobologram of the interaction between two drugs. (C) is the isobologram of the combination of three drugs in Figure 1.
Figure 2
Figure 2
Examples of rectangular hyperbolic dose-effect curves. (A) is the example of rectangular hyperbolic dose-effect curves. (B) is the isobologram of the interaction between two drugs.
Figure 3
Figure 3
The typical subadditive and superadditive isoboles.
See this image and copyright information in PMC

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