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Review
. 2019 Oct 29:10:1223.
doi: 10.3389/fphar.2019.01223. eCollection 2019.

Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre

Farzana Khan  1   2 , Md Moklesur Rahman Sarker  1   2 , Long Chiau Ming  3   4 , Isa Naina Mohamed  5 , Chao Zhao  6 , Bassem Y Sheikh  7 , Hiew Fei Tsong  8 , Mohammad A Rashid  9
Affiliations
Review

Comprehensive Review on Phytochemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre

Farzana Khan et al. Front Pharmacol. .

Abstract

Gymnema sylvestre is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. This plant is widely used as a traditional therapy for different purposes. Even now it is being used as a dietary supplement due to its numerous therapeutic uses. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. It renders glucose lowering activity due to the presence of phytochemicals, such as gurmarin, gymnemic acid as well as gymnemasaponins. Gymnema sylvestre is also known to have anti-oxidant, antibiotic, anti-inflammatory, antiviral, gastro and hepatoprotective, anticancer and lipid-lowering activities. This review discusses in details on different pharmacological and clinical potentials of Gymnema sylvestre and its chemical constituents associated with its therapeutic potentials.

Keywords: Gymnema sylvestre; antidiabetic; complementary and alternative medicine; herbal medicine; immunomodulating; lipid lowering; phytomedicine; traditional medicine.

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Figures

Figure 1
Figure 1
Phamacological activities of the constituents of Gymnema sylvestre.
Figure 2
Figure 2
Mechanism of glucose lowering activity by Gymnema sylvestre.
See this image and copyright information in PMC

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