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Case Reports
. 2019 Oct 31:26:61-63.
doi: 10.1016/j.mmcr.2019.10.007. eCollection 2019 Dec.

Presentation of histoplasmosis as mononucleosis syndrome in an immunocompetent patient

Mercedes Olaya-C  1   2 , Andrés Duarte  1   2 , Sandra L Valderrama  1   2
Affiliations
Case Reports

Presentation of histoplasmosis as mononucleosis syndrome in an immunocompetent patient

Mercedes Olaya-C et al. Med Mycol Case Rep. .

Abstract

Histoplasmosis is a fungal disease usually occurring in endemic areas that can affect immuno-impaired patients in whom pulmonary involvement is the rule. We present the case of an 18 year-old immunocompetent, male patient, resident of the State of Florida, who showed signs of mononucleosis syndrome that included odynophagia, cervical adenomegaly, sporadic fever and rash; however, no pulmonary involvement or visceromegaly were present. Faced with this atypical and unexpected clinical picture, histoplasmosis infection was eventually diagnosed following cervical lymph-node biopsy. Disseminated histoplasmosis may have unexpected manifestations, as is pointed out in the case described below.

Keywords: Histoplasmosis; Immunocompetent patient; Mononucleosis syndrome.

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Conflict of interest statement

None of the authors has any potential or actual interests relevant to the topics discussed in this manuscript. This paper has been financed by the Pontificia Universidad Javeriana, Hospital Universitario San Ignacio in Bogota, Colombia.

Figures

Fig. 1
Fig. 1
Widespread skin rash.
Fig. 2
Fig. 2
Histological study: Left: lymph node with markedly distorted architecture; middle: epithelioid granulomas and profuse necrosis; right: intracytoplasmatic granules compatible with Histoplasma capsulatum.
See this image and copyright information in PMC

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