KEYNOTE-042: is lowering the PD-L1 threshold for first-line pembrolizumab monotherapy a good idea?

Affiliations

Editorial

Jose M Pacheco. Transl Lung Cancer Res. 2019 Oct.

. 2019 Oct;8(5):723-727.

doi: 10.21037/tlcr.2019.05.03.

¹ Thoracic Oncology Program, Division of Medical Oncology, Department of Internal Medicine, University of Colorado Cancer Center, Aurora, CO, USA.

No abstract available

Conflict of interest statement

Conflicts of Interest: Honorarium from Genentech and Takeda. Consulting for AstraZeneca and Novartis. Research support from Pfizer.

Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial.
Mok TSK, Wu YL, Kudaba I, Kowalski DM, Cho BC, Turna HZ, Castro G Jr, Srimuninnimit V, Laktionov KK, Bondarenko I, Kubota K, Lubiniecki GM, Zhang J, Kush D, Lopes G; KEYNOTE-042 Investigators. Mok TSK, et al. Lancet. 2019 May 4;393(10183):1819-1830. doi: 10.1016/S0140-6736(18)32409-7. Epub 2019 Apr 4. Lancet. 2019. PMID: 30955977 Clinical Trial.

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