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Review
. 2019 Nov 14;11(11):1062.
doi: 10.3390/v11111062.

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Adithya Sridhar  1 , Eveliina Karelehto  1 , Lieke Brouwer  1 , Dasja Pajkrt  2 , Katja C Wolthers  1
Affiliations
Review

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Adithya Sridhar et al. Viruses. .

Abstract

ParechovirusA is a species in the Parechovirus genus within the Picornaviridae family that can cause severe disease in children. Relatively little is known on ParechovirusA epidemiology and pathogenesis. This review aims to explore the ParechovirusA literature and highlight the differences between ParechovirusA genotypes from a pathogenesis standpoint. In particular, the curious case of Parechovirus-A3 and the genotype-specific disease association will be discussed. Finally, a brief outlook on ParechovirusA research is provided.

Keywords: parechovirus; parechovirus A; parechovirus A-3; pathogenesis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Twofold axis of symmetry of PeV-A3 (Parechovirus A) at 4.3 Å resolution, canyon indicated by the arrow, (b) representative fit of the VP0 atomic model, and (c) capsid model showing positions of VP0 (yellow), VP1 (red), and VP3 (green). In blue are the symmetry axes—fivefold pentagon, threefold triangle, and twofold ellipse. Image used under the terms of the Creative Commons Attribution License (CC BY 4.0.) from Shakeel, S. et al., 2016 [6].
Figure 2
Figure 2
Immunofluorescence image of human airway epithelia (HAE) inserts infected with PeV-A1 and PeV-A3. Both genotypes appear to have a tropism for basal cells in the airway epithelium. Legend: Blue—DAPI (nuclei), Red—β-tub (ciliated cells), Green—PeV-A, and purple—p63 (basal cells). Image used under the terms of the Creative Commons Attribution License (CC BY 4.0.) from Karelehto E. et al., 2018 [83].
See this image and copyright information in PMC

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