Contemporary Issues in Breast Cancer Radiotherapy

Abstract

A series of landmark studies have increasingly emphasized the role of adjuvant radiotherapy for the definitive management of breast cancer. Although regional nodal irradiation, including the internal mammary nodes, was typically reserved for high-risk patients, there is now evidence of benefit to this approach even for those with a limited nodal disease burden. Similarly, low-risk disease has historically been treated with whole-breast tangents, although contemporary studies now support accelerated partial breast irradiation or the omission of radiotherapy in select cases. This article presents recent data informing these contemporary developments in the radiotherapeutic management of breast cancer.

Keywords: Adjuvant therapy; Breast cancer; Breast conservation; Lumpectomy; Postmastectomy radiation; Radiotherapy; Regional nodal irradiation.