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. 2019 Oct;71(Suppl 1):566-573.
doi: 10.1007/s12070-018-1410-8. Epub 2018 Jun 4.

Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate

Siddharth Panditray  1 , Sauvagini Acharya  1 , Nilamadhab Prusty  1 , Subha Saumya Dany  2
Affiliations

Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate

Siddharth Panditray et al. Indian J Otolaryngol Head Neck Surg. 2019 Oct.

Abstract

Management of head and neck hemangiomas with oral propranolol versus oral itraconazole in conjugation with injection sodium tetra decyl sulphate. This prospective parallel clinical trial was done to check for the effectiveness of oral propranolol and oral itraconazole when used in conjugation with inj. sodium tetra decyl sulphate in treatment of head and neck haemangiomas in adult patients visiting department of ENT and head and neck surgery, VIMSAR, Burla. All the patients visiting the department with hemangioma (diagnosed clinically and by FNAC) were considered and only those who gave written informed consent and were according to our inclusion and exclusion criteria were included into the study as subjects. Dimension (length, width and hemi-circumference) of the haemangiomas were measured using disposable paper taper measures. Depth of the hemangioma was calculated based on formula and using that volume was calculated both at baseline and after 8 weeks of drug administration. Data so collected was entered into Microsoft Office Excel 2013 and statistical analysis was performed using SPSS Version 20.0. Descriptive statistics was calculated and student's t test (paired and unpaired) was used to compare within the group (before and after) and between the groups respectively. Statistical significance was set at p ≤ 0.05. Both the groups showed statistically significant volume reduction in the lesions [p < 0.018 (propranolo + sodium tetra decyl sulphate), p < 0.025 (itraconazole + sodium tetra decyl sulphate)]. The mean decrease in volume in propranolol group was 91.92% and that in itraconazole group was 88.97%. There was no statistical difference between the final outcome of both the groups (p < 0.766) but 3 patients on propranolol had complete resolution while 1 patient on itraconazole had complete resolution of the lesion. Oral propranolol and itraconazole are both effective and safe in hemangioma in adults. The combination with inj. sodium tetra decyl sulphate has a (1) favorable impact on decreasing the overall duration of treatment. (2) Aiding in complete resolution of lesions (especially < 3 cm). Propranolol has an edge over itraconazole (more no of tumors had complete resolution).

Keywords: Hemangiomas; Itraconazole; Propranolol; Sclerotherapy.

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Conflict of interest statement

Conflict of interestThe authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Mechanism of action of propranolol in inhibiting angiogenesis
None
Length (a), Width (b), Hemi Circumference (m), Depth (c)
Fig. 2
Fig. 2
Mechanism of action of itraconazole in inhibiting angiogenesis [39]
Fig. 3
Fig. 3
Endoplasmic reticulum(er) cholesterol transport [40]
See this image and copyright information in PMC

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