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Case Reports
. 2019 Oct 31;8(10):3422-3424.
doi: 10.4103/jfmpc.jfmpc_628_19. eCollection 2019 Oct.

Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera

Akanksha Singh  1 , Subodh Kumar Mahto  1 , Jyotsana Prasad  2 , Suman Sharma  3 , Ashwani Kumar Malhotra  1
Affiliations
Case Reports

Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera

Akanksha Singh et al. J Family Med Prim Care. .

Abstract

Polycythemia vera (PV) is a myeloproliferative disorder most commonly associated with JAK2V617F mutation. Cerebral venous sinus thrombosis (CVST) has a wide range of etiologies and PV is one of them. CVST associated with PV has a poor prognosis. Some patients with classical PV lack JAK2V617F mutation and the molecular basis of JAK2V617F-negative PV is not known. We hereby report a case of a young man who presented with headache, vomiting and altered sensorium and was found to have recurrent CSVT. The patient had primary polycythemia and was subsequently diagnosed to have JAK2-negative PV.

Keywords: Cerebral venous sinus thrombosis; JAK2V617F negative; polycythemia vera.

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Conflict of interest statement

There is no conflicts of interest.

Figures

Figure 1
Figure 1
NCCT brain of patient showing the areas of haemorrhage in bilateral cerebral hemispheres, with largest 74 × 57 mm in left frontal lobe and with midline shift of 13 mm to right side
Figure 2
Figure 2
MRI and MR venography brain showing Superior sagittal sinus thrombosis with partial thrombosis of right transverse sinus with a large bleed in left frontal region causing mass effect and midline shift
See this image and copyright information in PMC

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