Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2019 Dec;25(12):2253-2256.
doi: 10.3201/eid2512.180712.

Multicountry Analysis of Spectrum of Clinical Manifestations of Children <5 Years of Age Hospitalized with Diarrhea

Jillian Murray, S Yati Soenarto, Nenny S Mulyani, Pushpa S Wijesinghe, Evans M Mpabalwani, Julia C Simwaka, Belem Matapo, Jason M Mwenda, Gayane Sahakyan, Svetlana Grigoryan, Artavazd Vanyan, Sergey Khactatryan, Jennifer Sanwogou, Lúcia Helena de Oliveira, Gloria Rey-Benito, Gagandeep Kang, Fatima Serhan, Jacqueline E Tate, Negar Aliabadi, Adam L Cohen; Global Rotavirus Surveillance Network Clinical Presentation Group
Collaborators
Multicenter Study

Multicountry Analysis of Spectrum of Clinical Manifestations of Children <5 Years of Age Hospitalized with Diarrhea

Jillian Murray et al. Emerg Infect Dis. 2019 Dec.

Abstract

After introduction of rotavirus vaccine, other pathogens might become leading causes of hospitalizations for severe diarrhea among children <5 years of age. Our study in 33 hospitals in 7 countries found acute gastroenteritis accounted for most (84%) reported hospitalizations of children with diarrhea. Bloody and persistent diarrhea each accounted for <1%.

Keywords: Armenia; Bolivia; El Salvador; India; Indonesia; Paraguay; Zambia; child surveillance; children; clinical manifestations; diarrhea; enteric infections; hospitalizations; multicountry analysis; rotavirus; spectrum; viruses.

PubMed Disclaimer

References

    1. Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al.; GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1459–544. 10.1016/S0140-6736(16)31012-1 - DOI - PMC - PubMed
    1. Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J, Parashar UD; WHO-coordinated Global Rotavirus Surveillance Network. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12:136–41. 10.1016/S1473-3099(11)70253-5 - DOI - PubMed
    1. World Health Organization. Rotavirus vaccines. WHO position paper – January 2013. Wkly Epidemiol Rec. 2013;88:49–64. - PubMed
    1. Operario DJ, Platts-Mills JA, Nadan S, Page N, Seheri M, Mphahlele J, et al. Etiology of severe acute watery diarrhea in children in the global rotavirus surveillance network using quantitative polymerase chain reaction. J Infect Dis. 2017;216:220–7. 10.1093/infdis/jix294 - DOI - PMC - PubMed
    1. Banajeh SM, Abu-Asba BA. The epidemiology of all-cause and rotavirus acute gastroenteritis and the characteristics of rotavirus circulating strains before and after rotavirus vaccine introduction in Yemen: analysis of hospital-based surveillance data. BMC Infect Dis. 2015;15:418. 10.1186/s12879-015-1165-8 - DOI - PMC - PubMed

Publication types

MeSH terms