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Case Reports
. 2020 Jan 7;100(1):adv00016.
doi: 10.2340/00015555-3371.

A Case of Four Synchronous Cutaneous Melanomas: Melanocortin 1 Receptor Polymorphisms and Excessive Sun Exposure

Giulia Gasparini  1 , Giulia Ciccarese, Emanuele Cozzani, William Bruno, Francesco Cabiddu, Margherita Cioni, Michele Paudice, Aurora Parodi
Affiliations
Case Reports

A Case of Four Synchronous Cutaneous Melanomas: Melanocortin 1 Receptor Polymorphisms and Excessive Sun Exposure

Giulia Gasparini et al. Acta Derm Venereol. .
No abstract available

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Figures

Fig. 1
Fig. 1
Clinical, dermoscopic, histopathological and immunohistochemical Melan-A staining of the 4 synchronous melanomas. (A, E, I, M) Melanoma of the left dorsum; (B, F, J, N) melanoma of the left shoulder; (C, G, K, O) melanoma of the right leg; and (D, H, L, P) melanoma of the right thigh. (A–D) All lesions shared similar clinical findings, presenting as light-brown macules with irregular borders and red-pink-white. (E–H) Dermoscopy revealed common features in all 4 lesions. (E) Multicomponent pattern, milky red areas, a regression area, shiny white streaks. (F) Multicomponent pattern, brownish homogenous areas, regression areas, and polymorphic vessels. (G) Multicomponent pattern, central brownish homogenous area, regression area with peppering. (H) Multicomponent milky red area, shiny streaks and polymorphic vessels. (I–P) Histopathological and immunohistochemical images (haematoxylin-eosin stain, Melan-A stain; original magnification ×10). All 4 melanocytic lesions were large (>10 mm of maximum diameter). They consisted of epidermal atypical melanocytic proliferation with a predominant lentiginous growth pattern and focally with pagetoid extension of atypical melanocytes up to the granular layer. For both the melanocytic atypia and the proliferation pattern, a diagnosis of melanoma was confirmed. Immunohistochemical assay for Melan-A helped in displaying the proliferation pattern.
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