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Comment
. 2019 Nov 18;51(4):417-419.
doi: 10.1016/j.devcel.2019.10.028.

Role Reversal: A Pro-metastatic Function of E-Cadherin

Minhong Shen  1 , Yibin Kang  2
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Role Reversal: A Pro-metastatic Function of E-Cadherin

Minhong Shen et al. Dev Cell. .
Free article

Abstract

Carcinoma cells often acquire mobility and invasiveness by undergoing epithelial-to-mesenchymal transition, and yet most metastatic lesions remain epithelial in nature. Recently, in Nature, Padmanaban et al. (2019) demonstrated that the quintessential epithelial marker E-cadherin promotes metastasis of invasive ductal breast carcinoma by enhancing the survival of tumor cells.

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