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Review
. 2019 Nov 16;8(11):2001.
doi: 10.3390/jcm8112001.

Should We Offer In Vitro Fertilization to Couples with Unexplained Recurrent Pregnancy Loss?

Michal Kirshenbaum  1   2 , Raoul Orvieto  1   2   3
Affiliations
Review

Should We Offer In Vitro Fertilization to Couples with Unexplained Recurrent Pregnancy Loss?

Michal Kirshenbaum et al. J Clin Med. .

Abstract

In clinical practice, empirical treatments are often offered to couples with recurrent pregnancy loss, including in vitro fertilization. Given that most patients with recurrent pregnancy loss are fertile, the scientific rationale of in vitro fertilization for these couple is debatable. This review will discuss the potential benefits of using in vitro fertilization in couples with recurrent pregnancy loss, such as shortening the time to conceive, optimizing the timing of conception, improving gamete and embryo quality, endometrial receptivity and the use of "adds-on". At present, there is not enough evidence to justify IVF as a treatment option in couples with unexplained recurrent pregnancy loss.

Keywords: ART; IVF; adds-on; outcome; repeated pregnancy loss.

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Conflict of interest statement

The authors declare no conflicts of interest.

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