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. 1988 Sep 26;16(18):8999-9016.
doi: 10.1093/nar/16.18.8999.

A molecular model for proflavine-DNA intercalation

S Neidle  1 , L H Pearl, P Herzyk, H M Berman
Affiliations
Free PMC article

A molecular model for proflavine-DNA intercalation

S Neidle et al. Nucleic Acids Res. .
Free PMC article

Abstract

A molecular model has been derived for the intercalation of proflavine into the CpG site of the decamer duplex of d(GATACGATAC). The starting geometry of the intercalation site was taken from previous crystallographic studies on the d(CpG)-proflavine complex, and molecular mechanics used to obtain a stereochemically acceptable structure. This has widened grooves compared to standard A- or B- double helices, as well as distinct conformational, roll, twist and tilt features.

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References

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