Travelling Together: A Unifying Pathomechanism for ALS

Pietro Fratta¹, Nicol Birsa², Andrew P Tosolini³, Giampietro Schiavo⁴

Affiliations

¹ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: p.fratta@ucl.ac.uk.
² Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK.
³ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
⁴ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK; Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK. Electronic address: giampietro.schiavo@ucl.ac.uk.

PMID: 31744630
DOI: 10.1016/j.tins.2019.10.006

Comment

Travelling Together: A Unifying Pathomechanism for ALS

Pietro Fratta et al. Trends Neurosci. 2020 Jan.

. 2020 Jan;43(1):1-2.

doi: 10.1016/j.tins.2019.10.006. Epub 2019 Nov 16.

Authors

Pietro Fratta¹, Nicol Birsa², Andrew P Tosolini³, Giampietro Schiavo⁴

Affiliations

¹ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: p.fratta@ucl.ac.uk.
² Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK.
³ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
⁴ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK; Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK. Electronic address: giampietro.schiavo@ucl.ac.uk.

PMID: 31744630
DOI: 10.1016/j.tins.2019.10.006

Abstract

Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting that RNA granules 'hitchhike' on LAMP1-positive organelles using annexin A11 as a tether.

Keywords: LAMP1-positive organelles; RNA granules; amyotrophic lateral sclerosis; annexin A11; axonal transport.

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RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.
Liao YC, Fernandopulle MS, Wang G, Choi H, Hao L, Drerup CM, Patel R, Qamar S, Nixon-Abell J, Shen Y, Meadows W, Vendruscolo M, Knowles TPJ, Nelson M, Czekalska MA, Musteikyte G, Gachechiladze MA, Stephens CA, Pasolli HA, Forrest LR, St George-Hyslop P, Lippincott-Schwartz J, Ward ME. Liao YC, et al. Cell. 2019 Sep 19;179(1):147-164.e20. doi: 10.1016/j.cell.2019.08.050. Cell. 2019. PMID: 31539493 Free PMC article.

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Travelling Together: A Unifying Pathomechanism for ALS

Affiliations

Travelling Together: A Unifying Pathomechanism for ALS

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Substances

Supplementary concepts

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous