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. 1988 Oct;85(20):7471-5.
doi: 10.1073/pnas.85.20.7471.

Modifying preselected sites on proteins: the stretch of residues 633-642 of the myosin heavy chain is part of the actin-binding site

P Chaussepied  1 , M F Morales
Affiliations

Modifying preselected sites on proteins: the stretch of residues 633-642 of the myosin heavy chain is part of the actin-binding site

P Chaussepied et al. Proc Natl Acad Sci U S A. 1988 Oct.

Abstract

We have designed an "antipeptide" capable of firmly and specifically interacting with a preselected stretch of myosin S-1 heavy chain. Covalent attachment of this antipeptide to its target stretch, residues 633-642, does not affect the intrinsic ATPase activities of the protein but significantly reduces the actin-binding capabilities of the myosin head.

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